Percodan Pill (Oxycodone + Aspirin) for Moderate to Severe Pain – Available Nationwide (All 53 States)
(Target Keywords: Percodan Pill, Percodan 325/4 mg, Percodan, oxycodone aspirin, Percodan USA)
H2 – What Is Percodan Pill? (Percodan 325/4 mg Explained)
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Percodan is a prescription combination pain medication containing oxycodone (an opioid analgesic) and aspirin (an NSAID anti-inflammatory), dosed typically at ~4.8355 mg oxycodone HCl (≈4.33 mg free base) with 325 mg aspirin per tablet WikipediaDrugs.comRxList.
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Marketed since the 1950s (initially by DuPont, now Endo Pharmaceuticals) Wikipedia.
H2 – Percodan vs. Percocet: Key Differences for U.S. Patients
H3 – Formulation Comparison
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Percodan = Oxycodone + Aspirin Pyramid HealthcareHealth Recovery TipsWikipedia.
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Percocet = Oxycodone + Acetaminophen (Tylenol) Pyramid HealthcareHealth Recovery Tips.
H3 – Safety & Side Effects
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Aspirin in Percodan increases risk of gastrointestinal irritation, ulcers, bleeding Pyramid HealthcareWebMD.
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Acetaminophen in Percocet poses liver toxicity risk at high doses Pyramid HealthcareHealth Recovery Tips.
H3 – Abuse & Overdose Risks
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Opioid (oxycodone) component carries risk of addiction, respiratory depression, overdose in both drugs Pyramid HealthcareWebMDRxList.
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Percodan’s aspirin adds bleeding complications; Percocet adds liver damage potential Pyramid HealthcareHealth Recovery Tips.
H2 – Percodan Uses, Dosage & How It Works
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Used for moderate to moderately severe pain when alternatives aren’t effective, e.g., post-surgery, injury, dental pain Mayo ClinicMedscape ReferenceRxList.
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Typical dosage: 1 tablet every 6 hours as needed, maximum 12 tablets/day (limit aspirin to 4 g/day) Medscape ReferenceRxList.
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Mechanism: Oxycodone relieves pain via central opioid receptors; aspirin reduces inflammation and pain via prostaglandin inhibition Medscape ReferenceRxListWebMD.
H2 – Warnings, Precautions & Storage
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Addiction & Dependence: Always use under medical supervision. Risk evaluation (REMS) applies Mayo ClinicRxList.
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Serious Side Effects: Respiratory depression, GI bleeding, allergic reactions (e.g., anaphylaxis, DRESS) WebMDRxList.
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Drug Interactions: Avoid CNS depressants (e.g., benzodiazepines, alcohol), anticoagulants, other NSAIDs, etc. WebMDRxList.
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Special Populations: Not for children due to Reye’s syndrome risk; avoid in late pregnancy and during breastfeeding WebMD+1.
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Storage: Keep at room temperature (68–77°F), in a cool, dry place WebMD.
H2 – Percodan Availability by State (All 53 U.S. Regions)
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Percodan (including brand Endodan) was widely prescribed across the U.S.; some formulations (e.g., Percodan) have been discontinued GoodRx.
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It is a Schedule II controlled substance in all states due to its high abuse potential Drugs.comRxList.
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Availability can vary by state—consult your state regulatory and Rx provider for current prescribing rules.
H2 – FAQs: Percodan Pill (Oxycodone + Aspirin)
H3 – What is Percodan used for?
To relieve moderate to severe pain when non‑opioid treatments fail Mayo ClinicRxList.
H3 – What’s inside each Percodan tablet?
Each contains about 4.8355 mg oxycodone HCl (≈ 4.33 mg free base) and 325 mg aspirin, plus inactive dyes and fillers WikipediaDrugs.comRxList.
H3 – Is Percodan still available in the U.S.?
Some formulations have been discontinued; availability may depend on state and manufacturer remaining stocks GoodRx.
H3 – How often can I take Percodan safely?
Typically 1 tablet every 6 hours as needed, not exceeding 12/day or 4 g aspirin per 24 hours Medscape ReferenceRxList.
H3 – How does Percodan differ from Percocet?
Percodan includes aspirin (raises bleeding risk), whereas Percocet includes acetaminophen (raises liver risk) Pyramid HealthcareHealth Recovery Tips.
H3 – What are common side effects of Percodan?
Drowsiness, nausea, dizziness, constipation, stomach pain; serious effects include bleeding, respiratory depression, allergic reactions WebMDRxList.
H3 – What should I avoid while taking it?
Avoid alcohol, other sedatives, blood thinners, other NSAIDs; consult your doctor about other medications WebMDRxList.
H3 – What if I overdose on Percodan?
Signs include shallow breathing, unconsciousness, slow heart rate. Naloxone may reverse opioid effects—seek immediate medical help WebMDRxList.
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